Doxycycline HCL
| Tests | Standards | |
1 | Characteristics | A yellow crystalline powder hygroscopic | |
2 | identification | TLC | |
Sulphuric acid yellow colour reaction | |||
Choride’s reaction | |||
3 | Acidity | PH 2.0-3.0 | |
4 | Absorbance | 300-330 | |
5 | Specific optical rotation | -105º~ -`120º | |
6 | Heavy metals | Not more than 50PPM | |
7 | Light-absorbing impurities | Not more than 0.07 | |
8 | Related substances | Methacycline HCL | Not more than2.0% |
6-epi doxycycline | Not more than 2.0% | ||
Other impurities | Not more than 0.5% | ||
9 | Ethanol | 4.3%-6.0% | |
10 | Sulphated ash | Not more than 0.4% | |
11 | Water | 1.4%-2.8% | |
12 | Assay (ankydrous ethanol free) | 88.0%-94.0% | |
